Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

Abstract

For more than 100 years metal complexes have been extensively used in therapy and since the discovery of cisplatin the research in this field has expanded exponentially. The scientific community is always in search of new alternatives to platinum compounds and a wide variety of metallodrugs based on other metals have been reported with excellent therapeutic results. This short review focuses on the work that our research group has carried out since 2007 in collaboration with others and centers on the preparation of organogallium(III) compounds, organotin(IV) derivatives, and titanocene(IV) complexes together with the study of their cytotoxic anticancer properties.

Keywords

• metallodrugs
• cisplatin
• gallium
• tin
• titanium
• cancer
• nanostructures