Light-induced antimicrobial activities of porphyrin derivatives as photosensitizers
Shengman Yu,
Jingwei Shi,
Tingting Sun,
Zhigang Xie,
Liyuan Sun
Affiliations
Shengman Yu
School of Laboratory Medicine, Beihua University, 3999 Binjiang East Road, Jilin, Jilin 132013, People’s Republic of China
Jingwei Shi
Department of Laboratory Medicine Center, China-Japan Union Hospital, Jilin University, 126 Xiantai Street, Changchun, Jilin 130033, People’s Republic of China
Tingting Sun
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People’s Republic of China
Zhigang Xie
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People’s Republic of China
Liyuan Sun
School of Laboratory Medicine, Beihua University, 3999 Binjiang East Road, Jilin, Jilin 132013, People’s Republic of China
Antimicrobial photodynamic therapy has considerable promise in the fight against bacterial infections. The superior photophysical characteristics of porphyrins have made them effective photosensitizers in the field of phototherapy. Herein, the light-induced antimicrobial effects of three porphyrins with different substituents have been compared. 5,10,15,20-tetrakis(4-hydroxyphenyl) porphyrin (THPP) shows superior photosensitizing activity and antimicrobial ability under irradiation with green light. THPP can also inhibit and destroy mature Staphylococcus aureus biofilms under irradiation. This work provides a reference for the rational design of photosensitizers for application in antimicrobial photodynamic therapy.
