A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

Sara M. Ambjørn; Julien P. Duxin; Emil P. T. Hertz; Isha Nasa; Joana Duro; Thomas Kruse; Blanca Lopez-Mendez; Beata Rymarczyk; Lauren E. Cressey; Thomas van Overeem Hansen; Arminja N. Kettenbach; Vibe H. Oestergaard; Michael Lisby; Jakob Nilsson

doi:10.1038/s41467-021-26079-0

Nature Communications (Sep 2021)

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

Sara M. Ambjørn,
Julien P. Duxin,
Emil P. T. Hertz,
Isha Nasa,
Joana Duro,
Thomas Kruse,
Blanca Lopez-Mendez,
Beata Rymarczyk,
Lauren E. Cressey,
Thomas van Overeem Hansen,
Arminja N. Kettenbach,
Vibe H. Oestergaard,
Michael Lisby,
Jakob Nilsson

Affiliations

Sara M. Ambjørn: The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Julien P. Duxin: The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Emil P. T. Hertz: The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Isha Nasa: Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth College
Joana Duro: The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Thomas Kruse: The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Blanca Lopez-Mendez: The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
Beata Rymarczyk: Department of Biology, University of Konstanz
Lauren E. Cressey: Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth College
Thomas van Overeem Hansen: Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet
Arminja N. Kettenbach: Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth College
Vibe H. Oestergaard: Department of Biology, University of Copenhagen
Michael Lisby: Department of Biology, University of Copenhagen
Jakob Nilsson: The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen

DOI: https://doi.org/10.1038/s41467-021-26079-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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BRCA2 plays a central role in facilitating DNA repair by homologous recombination (HR). Here the authors describe how BRCA2 forms a complex with the protein phosphatase PP2A-B56 in response to DNA damage, which is required for HR.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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