Nature Communications (Sep 2018)
Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
- Yuxuan Guo,
- Blake D. Jardin,
- Pingzhu Zhou,
- Isha Sethi,
- Brynn N. Akerberg,
- Christopher N Toepfer,
- Yulan Ai,
- Yifei Li,
- Qing Ma,
- Silvia Guatimosim,
- Yongwu Hu,
- Grigor Varuzhanyan,
- Nathan J. VanDusen,
- Donghui Zhang,
- David C. Chan,
- Guo-Cheng Yuan,
- Christine E. Seidman,
- Jonathan G. Seidman,
- William T. Pu
Affiliations
- Yuxuan Guo
- Department of Cardiology, Boston Children’s Hospital
- Blake D. Jardin
- Department of Cardiology, Boston Children’s Hospital
- Pingzhu Zhou
- Department of Cardiology, Boston Children’s Hospital
- Isha Sethi
- Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute
- Brynn N. Akerberg
- Department of Cardiology, Boston Children’s Hospital
- Christopher N Toepfer
- Department of Genetics, Harvard Medical School
- Yulan Ai
- Department of Cardiology, Boston Children’s Hospital
- Yifei Li
- Department of Cardiology, Boston Children’s Hospital
- Qing Ma
- Department of Cardiology, Boston Children’s Hospital
- Silvia Guatimosim
- Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais
- Yongwu Hu
- Department of Cardiology, Boston Children’s Hospital
- Grigor Varuzhanyan
- Division of Biology and Biological Engineering, California Institute of Technology
- Nathan J. VanDusen
- Department of Cardiology, Boston Children’s Hospital
- Donghui Zhang
- Department of Cardiology, Boston Children’s Hospital
- David C. Chan
- Division of Biology and Biological Engineering, California Institute of Technology
- Guo-Cheng Yuan
- Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute
- Christine E. Seidman
- Department of Genetics, Harvard Medical School
- Jonathan G. Seidman
- Department of Genetics, Harvard Medical School
- William T. Pu
- Department of Cardiology, Boston Children’s Hospital
- DOI
- https://doi.org/10.1038/s41467-018-06347-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
The processes regulating cardiomyocyte (CM) maturation are unclear. Here, the authors show that serum response factor regulates CM maturation only in neonatal CMs through stage-specific chromatin occupancy that affects cell size, sarcomere and transverse-tubule organization, and mitochondria
