Enhanced Bioavailability of Dihydrotanshinone I–Bovine Serum Albumin Nanoparticles for Stroke Therapy

Yanru Ren; Yicheng Feng; Kunyao Xu; Saisai Yue; Tiantian Yang; Kaili Nie; Man Xu; Haijun Xu; Xin Xiong; Fabian Körte; Mike Barbeck; Peisen Zhang; Luo Liu

doi:10.3389/fphar.2021.721988

Frontiers in Pharmacology (Aug 2021)

Enhanced Bioavailability of Dihydrotanshinone I–Bovine Serum Albumin Nanoparticles for Stroke Therapy

Yanru Ren,
Yicheng Feng,
Kunyao Xu,
Saisai Yue,
Tiantian Yang,
Kaili Nie,
Man Xu,
Haijun Xu,
Xin Xiong,
Fabian Körte,
Mike Barbeck,
Peisen Zhang,
Luo Liu

Affiliations

Yanru Ren: Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
Yicheng Feng: Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
Kunyao Xu: Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
Saisai Yue: Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
Tiantian Yang: Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
Kaili Nie: Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
Man Xu: Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
Haijun Xu: Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
Xin Xiong: NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany
Fabian Körte: NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany
Mike Barbeck: Institute of Material Science and Technology, Technical University of Berlin, Berlin, Germany
Peisen Zhang: Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
Luo Liu: Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China

DOI: https://doi.org/10.3389/fphar.2021.721988
Journal volume & issue: Vol. 12

Abstract

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Dihydrotanshinone I (DHT) is a natural component in Salvia miltiorrhiza and has been widely researched for its multiple bioactivities. However, poor solubility and biocompatibility of DHT limit its desirable application for clinical purposes. Herein, DHT was encapsulated with bovine serum albumin (BSA) to enhance bioavailability. Compared to free DHT, DHT–BSA NPs (nanoparticles) showed an improved solubility in normal saline and increased protection against hydrogen peroxide–induced oxidative damage in PC12 cells. In addition, DHT–BSA NPs administered by intravenous injection displayed a significant efficacy in the middle cerebral artery occlusion/reperfusion models, without any impact on the cerebral blood flow. In summary, DHT–BSA NPs show an enhanced bioavailability compared with free DHT and a successful penetration into the central nervous system for stroke therapy, demonstrating their application potential in cardio–cerebrovascular diseases.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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