Nature Communications (May 2021)

Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis

  • Michael Tyler,
  • Itay Tirosh

DOI
https://doi.org/10.1038/s41467-021-22800-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Epithelial cancer cells can transition into a mesenchymal phenotype to enable invasion and metastasis. Here, the authors use previously published single-cell and bulk RNA sequencing datasets to decouple the mesenchymal expression profiles of cancer and stromal cells.