TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling

Song Gao; Shuaibin Wang; Zhiying Zhao; Chao Zhang; Zhicao Liu; Ping Ye; Zhifang Xu; Baozhu Yi; Kai Jiao; Gurudatta A. Naik; Shi Wei; Soroush Rais-Bahrami; Sejong Bae; Wei-Hsiung Yang; Guru Sonpavde; Runhua Liu; Lizhong Wang

doi:10.1038/s41467-022-30409-1

Nature Communications (May 2022)

TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling

Song Gao,
Shuaibin Wang,
Zhiying Zhao,
Chao Zhang,
Zhicao Liu,
Ping Ye,
Zhifang Xu,
Baozhu Yi,
Kai Jiao,
Gurudatta A. Naik,
Shi Wei,
Soroush Rais-Bahrami,
Sejong Bae,
Wei-Hsiung Yang,
Guru Sonpavde,
Runhua Liu,
Lizhong Wang

Affiliations

Song Gao: Department of Genetics, University of Alabama at Birmingham
Shuaibin Wang: Department of Genetics, University of Alabama at Birmingham
Zhiying Zhao: Department of Genetics, University of Alabama at Birmingham
Chao Zhang: Department of Genetics, University of Alabama at Birmingham
Zhicao Liu: Department of Genetics, University of Alabama at Birmingham
Ping Ye: Department of Genetics, University of Alabama at Birmingham
Zhifang Xu: Department of Genetics, University of Alabama at Birmingham
Baozhu Yi: Department of Genetics, University of Alabama at Birmingham
Kai Jiao: Department of Genetics, University of Alabama at Birmingham
Gurudatta A. Naik: Department of O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham
Shi Wei: Department of O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham
Soroush Rais-Bahrami: Department of O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham
Sejong Bae: Department of O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham
Wei-Hsiung Yang: Department of Biomedical Sciences, Mercer University School of Medicine
Guru Sonpavde: Dana Farber Cancer Institute
Runhua Liu: Department of Genetics, University of Alabama at Birmingham
Lizhong Wang: Department of Genetics, University of Alabama at Birmingham

DOI: https://doi.org/10.1038/s41467-022-30409-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The β-tubulin family protein TUBB4A is highly expressed in cancer but it’s molecular role is unclear. Here, the authors show that TUBB4A is required to protect the nucleus from genomic instability during migration and that it’s over expression promotes cancer progression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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