Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach
Chenmala Karthika,
Agnieszka Najda,
Joanna Klepacka,
Mehrukh Zehravi,
Rokeya Akter,
Muhammad Furqan Akhtar,
Ammara Saleem,
Majed Al-Shaeri,
Banani Mondal,
Ghulam Md. Ashraf,
Priti Tagde,
Sarker Ramproshad,
Zubair Ahmad,
Farhat S. Khan,
Md. Habibur Rahman
Affiliations
Chenmala Karthika
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty 643001, India
Agnieszka Najda
Department of Vegetable and Herbal Crops, University of Life Science in Lublin, Doświadczalna Street 51A, 20280 Lublin, Poland
Joanna Klepacka
Department of Commodity Science and Food Analysis, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, Oczapowskiego 2, 10719 Olsztyn, Poland
Mehrukh Zehravi
Department of Clinical Pharmacy Girls Section, Prince Sattam Bin Abdul Aziz University, Alkharj 11942, Saudi Arabia
Rokeya Akter
Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
Muhammad Furqan Akhtar
Riphah Institute of Pharmaceutical Sciences, Lahore Campus, Riphah International University, Lahore 54950, Pakistan
Ammara Saleem
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan
Majed Al-Shaeri
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Banani Mondal
Department of Pharmacy, Ranada Prasad Shaha University, Narayanganj 1400, Bangladesh
Ghulam Md. Ashraf
Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Priti Tagde
Amity Institute of Pharmacy, Amity University, Noida 201301, India
Sarker Ramproshad
Department of Pharmacy, Ranada Prasad Shaha University, Narayanganj 1400, Bangladesh
Zubair Ahmad
Unit of Bee Research and Honey Production, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia
Farhat S. Khan
Biology Department, College of Arts and Sciences, Dehran Al-Junub, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia
Md. Habibur Rahman
Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
A brain tumor (BT) is a condition in which there is growth or uncontrolled development of the brain cells, which usually goes unrecognized or is diagnosed at the later stages. Since the mechanism behind BT is not clear, and the various physiological conditions are difficult to diagnose, the success rate of BT is not very high. This is the central issue faced during drug development and clinical trials with almost all types of neurodegenerative disorders. In the first part of this review, we focus on the concept of brain tumors, their barriers, and the types of delivery possible to target the brain cells. Although various treatment methods are available, they all have side effects or toxic effects. Hence, in the second part, a correlation was made between the use of resveratrol, a potent antioxidant, and its advantages for brain diseases. The relationship between brain disease and the blood–brain barrier, multi-drug resistance, and the use of nanomedicine for treating brain disorders is also mentioned. In short, a hypothetical concept is given with a background investigation into the use of combination therapy with resveratrol as an active ingredient, the possible drug delivery, and its formulation-based approach.
