Stereoselective Synthesis of Southern Fragment of Hantupeptin-A

Abstract

The stereo selective synthesis of the southern fragment (C21-C41) of Hantupeptin–A is described. The required stereochemistry of b-hydroxy-a-methyl acid unit was accomplished through Aldol reaction using Evan’s chiral auxiliary followed by the installation of terminal alkyne with Ohira–Bestmann reagent.

Keywords

• Hantupeptin A
• Aldol Reaction
• Stereoselective synthesis
• Peptide
• Evan’s auxiliary