Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19

Abstract

ABSTRACTAnimal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of this review is to summarize our current understanding of the pathogenesis of coronavirus disease 2019 (COVID-19) and the pathologic features that can be observed in several currently available animal models. Knowledge gained from studying these animal models of SARS-CoV-2 infection can help inform appropriate model selection for disease modelling as well as for vaccine and therapeutic developments.

Keywords

• Respiratory pathogens
• coronaviruses
• animal models
• pathology
• pathogenesis