Molecules
(Jan 2015)
Isoleojaponin, a New Halimane Diterpene Isolated from Leonurus japonicus
Hankui Wu,
Sensheng Wang,
Zhiyong Xu,
Shanshan Sun,
Haijuan Liu,
Jinjin Wang,
Yan E,
Yanyan Lv,
Xuelin Dong,
Gang Li,
Liping Zhang,
Yunfeng Shi
Affiliations
Hankui Wu
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Sensheng Wang
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Zhiyong Xu
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Shanshan Sun
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Haijuan Liu
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Jinjin Wang
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Yan E
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Yanyan Lv
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Xuelin Dong
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Gang Li
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Liping Zhang
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
Yunfeng Shi
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
DOI
https://doi.org/10.3390/molecules20010839
Journal volume & issue
Vol. 20,
no. 1
Abstract
Read online
Leojaponin (2), a labdane diterpene, was isolated from the EtOH extract of the herb of Leonurus japonicus together with a new halimane diterpene named isoleojaponin (1). Isoleojaponin has a new diterpene skeleton with a unique cross-conjugated α,β-unsaturated ketone system, Their structures were elucidated by physical and spectroscopic analysis, and the relative configuration of the chiral C-9 carbon was determined by a computational method, and analysis of its possible biogenesis pathways.
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