Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids

Yan Zhu; Xiaolan Chen; Chunchen Yuan; Guobao Li; Jingyu Zhang; Yingsheng Zhao

doi:10.1038/ncomms14904

Nature Communications (Apr 2017)

Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids

Yan Zhu,
Xiaolan Chen,
Chunchen Yuan,
Guobao Li,
Jingyu Zhang,
Yingsheng Zhao

Affiliations

Yan Zhu: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Xiaolan Chen: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Chunchen Yuan: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Guobao Li: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Jingyu Zhang: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Yingsheng Zhao: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University

DOI: https://doi.org/10.1038/ncomms14904
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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Palladium catalysed C-H functionalization ofsp3carbons typically requires the installation and subsequent removal of a temporary directing group. Here the authors report a method allowing C-H functionalization in carboxylic acids in which the carboxylate acts as a directing group.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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