Glioblastoma behavior study under different frequency electromagnetic field
Xiao-Wei Xiang,
Hao-Tian Liu,
Xiao-Nan Tao,
Yu-Lian Zeng,
Jing Liu,
Chen Wang,
Sai-Xi Yu,
Hui Zhao,
Yan-Jun Liu,
Ke-Fu Liu
Affiliations
Xiao-Wei Xiang
Academy for engineering & technology, Fudan University, Shanghai 200433, China
Hao-Tian Liu
Academy for engineering & technology, Fudan University, Shanghai 200433, China
Xiao-Nan Tao
School of information science and technology, Fudan University, Shanghai 200433, China
Yu-Lian Zeng
Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
Jing Liu
School of information science and technology, Fudan University, Shanghai 200433, China
Chen Wang
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Stomatological Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
Sai-Xi Yu
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Stomatological Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
Hui Zhao
School of information science and technology, Fudan University, Shanghai 200433, China; Corresponding author
Yan-Jun Liu
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Stomatological Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Corresponding author
Ke-Fu Liu
School of information science and technology, Fudan University, Shanghai 200433, China; Corresponding author
Summary: The tumor-treating fields (TTFields) technology has revolutionized the management of recurrent and newly diagnosed glioblastoma (GBM) cases. To ameliorate this treatment modality for GBM and other oncological conditions, it is necessary to understand the biophysical principles of TTFields better. In this study, we further analyzed the mechanism of the electromagnetic exposure with varying frequencies and electric field strengths on cells in mitosis, specifically in telophase. In reference to previous studies, an intuitive finite element model of the mitotic cell was built for electromagnetic simulations, predicting a local increase in the cleavage furrow region, which may help explain TTFields’ anti-proliferative effects. Cell experiments confirmed that the reduction in proliferation and migration of glioma cell by TTFields was in a frequency- and field-strength-dependent manner. This work provides unique insights into the selection of frequencies in the anti-proliferative effect of TTFields on tumors, which could improve the application of TTFields.
