Acta Cirúrgica Brasileira (Oct 2023)

Effects of Calendula officinalis extract on liver histopathology, lipid profile, and oxidative stress in rats submitted to a diet rich in cholesterol and carbohydrates

  • Gleide Gatti Fontes,
  • Rodrigo de Barros Freitas,
  • Palloma Porto Almeida,
  • Luciana Moreira Lima,
  • Silvia Almeida Cardoso,
  • Virginia Ramos Pizziolo,
  • Ricardo Tabach,
  • Almir Gonçalves Wanderley,
  • Ricardo Mario Arida,
  • Afonso Caricati-Neto,
  • Murched Omar Taha,
  • Camilo Amaro de Carvalho,
  • Fernando Sabia Tallo,
  • Francisco Sandro Menezes-Rodrigues

DOI
https://doi.org/10.1590/acb383723
Journal volume & issue
Vol. 38

Abstract

Read online

ABSTRACT Purpose: To evaluate the modulatory properties of Calendula officinalis L. (Asteraceae) (C. officinalis) extract on cafeteria diet-fed rats. Methods: A cafeteria diet was administered ad libitum for 45 days to induce dyslipidemia. Then, the rats were treated with the formulations containing C. officinalis in the doses of 50, 100, and 150 mg/kg or only with the vehicle formulation; the control group received a commercial ration. Results: The cafeteria diet decreased glutathione S-transferase activity and high-density lipoprotein plasmatic levels and damaged the hepatic architecture. The C. officinalis extract was able to reduce lipid infiltration in liver tissue and to modulate oxidative stress and lipid profile markers. Conclusions: The correlations between the variables suggest a pathological connection between oxidative stress markers and serum lipid profile.

Keywords