The Effect of Tegoprazan on the Treatment of Endoscopic Resection-Induced Artificial Ulcers: A Multicenter, Randomized, Active-Controlled Study
Byung-Wook Kim,
Jong Jae Park,
Hee Seok Moon,
Wan Sik Lee,
Ki-Nam Shim,
Gwang Ho Baik,
Yun Jeong Lim,
Hang Lak Lee,
Young Hoon Youn,
Jun Chul Park,
In-Kyung Sung,
Hyunsoo Chung,
Jeong Seop Moon,
Gwang Ha Kim,
Su Jin Hong,
Hyuk Soon Choi
Affiliations
Byung-Wook Kim
Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Jong Jae Park
Division of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
Hee Seok Moon
Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea
Wan Sik Lee
Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea
Ki-Nam Shim
Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea
Gwang Ho Baik
Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea
Yun Jeong Lim
Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea
Hang Lak Lee
Department of Internal Medicine, Hanyang University Medical Center, Seoul, Korea
Young Hoon Youn
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Jun Chul Park
Department of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
In-Kyung Sung
Department of Internal Medicine, Konkuk University Medical Center, Konkuk University College of Medicine, Seoul, Korea
Hyunsoo Chung
Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Jeong Seop Moon
Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea
Gwang Ha Kim
Department of Internal Medicine, Pusan National University College of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
Su Jin Hong
Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea
Hyuk Soon Choi
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Background/Aims: Tegoprazan is a novel potassium-competitive acid blocker that has beneficial effects on acid-related disorders such as gastroesophageal reflux and peptic ulcer diseases. This study aimed to validate the effect of tegoprazan on endoscopic submucosal dissection (ESD)-induced artificial ulcers. Methods : Patients from 16 centers in Korea who underwent ESD for gastric neoplasia were enrolled. After ESD, pantoprazole was administered intravenously for 48 hours. The patients were randomly allocated to either the tegoprazan or esomeprazole group. Tegoprazan 50 mg or esomeprazole 40 mg were administered for 4 weeks, after which gastroscopic evaluation was performed. If the artificial ulcer had not healed, the same dose of tegoprazan or esomeprazole was administered for an additional 4 weeks, and a gastroscopic evaluation was performed. Results : One hundred sixty patients were enrolled in this study. The healing rates of artificial ulcers at 4 weeks were 30.3% (23/76) and 22.1% (15/68) in the tegoprazan and esomeprazole groups, respectively (p=0.006). At 8 weeks after ESD, the cumulative ulcer healing rates were 73.7% (56/76) and 77.9% (53/68) in the tegoprazan and esomeprazole groups, respectively (p=0.210). Delayed bleeding occurred in two patients in the tegoprazan group (2.6%) and in one patient in the esomeprazole group (1.5%). Other adverse events were negligible in both groups. Conclusion : s: Tegoprazan showed similar effects on post-ESD artificial ulcer healing in comparison with esomeprazole.
