Role of ferroptosis and ferroptosis-related non-coding RNAs in the occurrence and development of gastric cancer

Ling Lu; Bei Chen; Bei Chen; Yumeng Xu; Xinyi Zhang; Longtao Jin; Hui Qian; Yi Wang; Zhao Feng Liang

doi:10.3389/fphar.2022.902302

Frontiers in Pharmacology (Aug 2022)

Role of ferroptosis and ferroptosis-related non-coding RNAs in the occurrence and development of gastric cancer

Ling Lu,
Bei Chen,
Bei Chen,
Yumeng Xu,
Xinyi Zhang,
Longtao Jin,
Hui Qian,
Yi Wang,
Zhao Feng Liang

Affiliations

Ling Lu: Child Healthcare Department, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, JS, China
Bei Chen: Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, JS, China
Bei Chen: Suzhou Science and Technology Town Hospital, Suzhou, JS, China
Yumeng Xu: Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, JS, China
Xinyi Zhang: Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, JS, China
Longtao Jin: Child Healthcare Department, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, JS, China
Hui Qian: Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, JS, China
Yi Wang: Department of Urology, the Second Hospital of Anhui Medical University, Hefei, China
Zhao Feng Liang: Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, JS, China

DOI: https://doi.org/10.3389/fphar.2022.902302
Journal volume & issue: Vol. 13

Abstract

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Gastric cancer (GC) is a malignant cancer of the digestive tract and is a life-threatening disease worldwide. Ferroptosis is a newly discovered form of regulated cell death, which involves the accumulation of iron-dependent lipid peroxides. It has been found that ferroptosis plays an important regulatory role in the occurrence, development, drug resistance, and prognosis of GC. Non-coding RNAs (ncRNAs) play a critical role in the occurrence and progression of a variety of diseases including GC. In recent years, the role of ferroptosis and ferroptosis-related ncRNAs (miRNA, lncRNA, and circRNA) in the occurrence, development, drug resistance, and prognosis of GC has attracted more and more attention. Herein, we briefly summarize the roles and functions of ferroptosis and ferroptosis-related ncRNAs in GC tumorigenesis, development, and prognosis. We also prospected the future research direction and challenges of ferroptosis and ferroptosis-related ncRNAs in GC.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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Abstract

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