Poly-Dianix Blue/Multi-Walled Carbon Nanotube Modified Electrode for Detection of Levodopa in the Presence of High Concentrations of Ascorbic and Uric Acids

Abstract

A selective and sensitive electrochemical sensor was studied for determination of levodopa (LD) in the presence of uric acid (UA) and ascorbic acid (AA) using poly-dianix blue and multi-walled carbon nanotubes (PDB/MWCNTs) modified glassy carbon electrode. Cyclic voltammetry, differential pulse voltammetry, and chronoamperometry methods were applied to investigate the electrocatalytic oxidation of LD, UA and AA in aqueous solutions. By DPV technique, LD, UA and AA give oxidation peaks at 0.380, 0.520 and 0.180 V, respectively. Under the optimized experimental conditions LD, UA and AA give a linear response in the range of 0.09‑75 µmol L-1, 0.3–110 µmol L-1 and 10–160 µmol L-1, respectively. Accordingly, the obtained detection limits were 0.003, 0.002 and 0.023 µmol L‑1. The method provides a simple electrochemical sensor for successful determination of LD in human blood serum samples.

Keywords

• Dianix Blue
• Carbon Nanotubes
• Modified Electrode
• Levodopa
• Uric Acid
• Ascorbic Acid.