Sleep quality differentially modulates neural oscillations and proteinopathy in Alzheimer's diseaseResearch in context
Maggie P. Rempe,
Alex I. Wiesman,
Daniel L. Murman,
Pamela E. May,
Nicholas J. Christopher–Hayes,
Sara L. Wolfson,
Craig M. Johnson,
Tony W. Wilson
Affiliations
Maggie P. Rempe
Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; University of Nebraska Medical Center (UNMC), College of Medicine, Omaha, NE, 68198, USA
Alex I. Wiesman
Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 0G4, Canada; Corresponding author. Montreal Neurological Institute, McGill University Montreal, Quebec, Canada.
Daniel L. Murman
University of Nebraska Medical Center (UNMC), College of Medicine, Omaha, NE, 68198, USA
Pamela E. May
University of Nebraska Medical Center (UNMC), College of Medicine, Omaha, NE, 68198, USA
Nicholas J. Christopher–Hayes
Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; Center for Mind and Brain, University of California, Davis, CA, 95618, USA
Sara L. Wolfson
University of Nebraska Medical Center (UNMC), College of Medicine, Omaha, NE, 68198, USA
Craig M. Johnson
University of Nebraska Medical Center (UNMC), College of Medicine, Omaha, NE, 68198, USA
Tony W. Wilson
Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, 68010, USA; University of Nebraska Medical Center (UNMC), College of Medicine, Omaha, NE, 68198, USA; Department of Pharmacology and Neuroscience, Creighton University, Omaha, NE, 68178 USA
Summary: Background: Alterations in resting-state neural activity have been reported in people with sleep disruptions and in patients with Alzheimer's disease, but the direct impact of sleep quality on Alzheimer's disease-related neurophysiological aberrations is unclear. Methods: We collected cross-sectional resting-state magnetoencephalography and extensive neuropsychological and clinical data from 38 biomarker-confirmed patients on the Alzheimer's disease spectrum and 20 cognitively normal older control participants. Sleep efficiency was quantified using the Pittsburgh Sleep Quality Index. Findings: Neural activity in the delta frequency range was differentially affected by poor sleep in patients on the Alzheimer's disease spectrum. Such neural changes were related to processing speed abilities and regional amyloid accumulation, and these associations were mediated and moderated, respectively, by sleep quality. Interpretation: Together, our results point to a mechanistic role for sleep disturbances in the widely reported neurophysiological aberrations seen in patients on the Alzheimer's disease spectrum, with implications for basic research and clinical intervention. Funding: National Institutes of Health, USA.
