Nature Communications (Nov 2022)

Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress

  • Ronghui Yang,
  • Chuanzhen Yang,
  • Lingdi Ma,
  • Yiliang Zhao,
  • Zihao Guo,
  • Jing Niu,
  • Qiaoyun Chu,
  • Yingmin Ma,
  • Binghui Li

DOI
https://doi.org/10.1038/s41467-022-34850-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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Reductive stress, reflected by the elevated intracellular NADH/NAD+ ratio, is associated with multiple human diseases. Here, the authors develop a genetic tool to manipulate the ratios of cellular NADH/NAD+ and NADPH/NADP+, and identify purine biosynthesis as an NADH-sensing pathway to mediate reductive stress.