PLoS ONE (Jan 2020)

Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection.

  • Lauren Korhonen,
  • Jessica Cohen,
  • Nicole Gregoricus,
  • Monica M Farley,
  • Rebecca Perlmutter,
  • Stacy M Holzbauer,
  • Ghinwa Dumyati,
  • Zintars Beldavs,
  • Ashley Paulick,
  • Jan Vinjé,
  • Brandi M Limbago,
  • Fernanda C Lessa,
  • Alice Y Guh

DOI
https://doi.org/10.1371/journal.pone.0240549
Journal volume & issue
Vol. 15, no. 10
p. e0240549

Abstract

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We assessed viral co-infections in 155 patients with community-associated Clostridioides difficile infection in five U.S. sites during December 2012-February 2013. Eighteen patients (12%) tested positive for norovirus (n = 10), adenovirus (n = 4), rotavirus (n = 3), or sapovirus (n = 1). Co-infected patients were more likely than non-co-infected patients to have nausea or vomiting (56% vs 31%; p = 0.04), suggesting that viral co-pathogens contributed to symptoms in some patients. There were no significant differences in prior healthcare or medication exposures or in CDI complications.