Nature Communications (Apr 2022)
USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma
- Zhen Ning,
- Xin Guo,
- Xiaolong Liu,
- Chang Lu,
- Aman Wang,
- Xiaolin Wang,
- Wen Wang,
- Huan Chen,
- Wangshu Qin,
- Xinyu Liu,
- Lina Zhou,
- Chi Ma,
- Jian Du,
- Zhikun Lin,
- Haifeng Luo,
- Wuxiyar Otkur,
- Huan Qi,
- Di Chen,
- Tian Xia,
- Jiwei Liu,
- Guang Tan,
- Guowang Xu,
- Hai-long Piao
Affiliations
- Zhen Ning
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Xin Guo
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Xiaolong Liu
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Chang Lu
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Aman Wang
- The First Affiliated Hospital of Dalian Medical University, Dalian Medical University
- Xiaolin Wang
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Wen Wang
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Huan Chen
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Wangshu Qin
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Xinyu Liu
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Lina Zhou
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Chi Ma
- The First Affiliated Hospital of Dalian Medical University, Dalian Medical University
- Jian Du
- The First Affiliated Hospital of Dalian Medical University, Dalian Medical University
- Zhikun Lin
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Haifeng Luo
- The First Affiliated Hospital of Dalian Medical University, Dalian Medical University
- Wuxiyar Otkur
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Huan Qi
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Di Chen
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Tian Xia
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Jiwei Liu
- The First Affiliated Hospital of Dalian Medical University, Dalian Medical University
- Guang Tan
- The First Affiliated Hospital of Dalian Medical University, Dalian Medical University
- Guowang Xu
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- Hai-long Piao
- CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-022-29846-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Different deubiquitinases are associated to cancer development. Here, the authors show that PPARgamma is stabilized by USP22-mediated deubiquitination leading to lipid accumulation and promoting hepatocellular carcinoma.
