Potential global impacts of alternative dosing regimen and rollout options for the ChAdOx1 nCoV-19 vaccine

Ricardo Aguas; Anouska Bharath; Lisa J. White; Bo Gao; Andrew J. Pollard; Merryn Voysey; Rima Shretta

doi:10.1038/s41467-021-26449-8

Nature Communications (Nov 2021)

Potential global impacts of alternative dosing regimen and rollout options for the ChAdOx1 nCoV-19 vaccine

Ricardo Aguas,
Anouska Bharath,
Lisa J. White,
Bo Gao,
Andrew J. Pollard,
Merryn Voysey,
Rima Shretta

Affiliations

Ricardo Aguas: Nuffield Department of Medicine, University of Oxford
Anouska Bharath: Nuffield Department of Medicine, University of Oxford
Lisa J. White: Nuffield Department of Medicine, University of Oxford
Bo Gao: Nuffield Department of Medicine, University of Oxford
Andrew J. Pollard: Oxford Vaccine Group, Department of Paediatrics, University of Oxford
Merryn Voysey: Oxford Vaccine Group, Department of Paediatrics, University of Oxford
Rima Shretta: Nuffield Department of Medicine, University of Oxford

DOI: https://doi.org/10.1038/s41467-021-26449-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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The ChAdOx1 nCoV-19 vaccine requires two doses, but under limited supply single dose regimens have also been considered. Here, the authors show using static transmission modelling that under certain conditions it is optimal to more expediently administer a single dose to a larger proportion of the population.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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