Increased EEG gamma power under exposure to drug-related cues: a translational index for cue-elicited craving in METH-dependent individuals

Abstract

Abstract Background This study explored the feasibility of using EEG gamma-band (30–49 Hz) power as an index of cue-elicited craving in METH-dependent individuals. Methods Twenty-nine participants dependent on methamphetamine (METH) and 30 healthy participants were instructed to experience a METH-related virtual reality (VR) social environment. Results Individuals with METH dependence showed significantly stronger self-reported craving and higher gamma power in a VR environment than healthy individuals. In the METH group, the VR environment elicited a significant increase in gamma power compared with the resting state. The METH group then received a VR counterconditioning procedure (VRCP), which was deemed useful in suppressing cue-induced reactivity. After VRCP, participants showed significantly lower self-reported craving scores and gamma power when exposed to drug-related cues than the first time. Conclusions These findings suggest that the EEG gamma-band power may be a marker of cue-induced reactivity in patients with METH dependence.

Keywords

• Methamphetamine
• Craving
• Virtual reality
• Counterconditioning
• Gamma oscillations