Effects of Anesthesia on Postoperative Recurrence and Metastasis of Malignant Tumors

Abstract

Xiaoqing Fan,1,2 Delong Wang,1,2 Xueran Chen,3,4 Ruiting Wang1,2 1Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, Anhui 230001, People’s Republic of China; 2Department of Anesthesiology, Anhui Provincial Hospital, Hefei 230001, Anhui, People’s Republic of China; 3Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, People’s Republic of China; 4Department of Molecular Pathology, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui 230031, People’s Republic of ChinaCorrespondence: Xueran Chen; Ruiting Wang Email [email protected]; [email protected]: It is difficult to control the recurrence and metastasis of malignant tumors; furthermore, anesthesia is considered one of the main influencing factors. There has been increasing clinical attention on the effects of anesthetic drugs and methods on postoperative tumor growth and metastasis. We reviewed the effects of anesthesia on tumor recurrence and metastasis; specifically, the effects of anesthetic agents, anesthesia methods, and related factors during the perioperative period on the tumor growth and metastasis were analyzed. This study can provide reference standards for rational anesthesia formulations and cancer-related pain analgesia protocols for surgical procedures in patients with malignant tumors. Moreover, it contributes toward an experimental basis for the improvement and development of novel anesthetic agents and methods.Keywords: anesthesia, cancer, recurrence, metastasis, prognosis, immunosuppression

Keywords

• anesthesia
• cancer
• recurrence
• metastasis
• prognosis
• immunosuppression