A high throughput bispecific antibody discovery pipeline

Aude I. Segaliny; Jayapriya Jayaraman; Xiaoming Chen; Jonathan Chong; Ryan Luxon; Audrey Fung; Qiwei Fu; Xianzhi Jiang; Rodrigo Rivera; Xiaoya Ma; Ci Ren; Jan Zimak; Per Niklas Hedde; Yonglei Shang; George Wu; Weian Zhao

doi:10.1038/s42003-023-04746-w

Communications Biology (Apr 2023)

A high throughput bispecific antibody discovery pipeline

Aude I. Segaliny,
Jayapriya Jayaraman,
Xiaoming Chen,
Jonathan Chong,
Ryan Luxon,
Audrey Fung,
Qiwei Fu,
Xianzhi Jiang,
Rodrigo Rivera,
Xiaoya Ma,
Ci Ren,
Jan Zimak,
Per Niklas Hedde,
Yonglei Shang,
George Wu,
Weian Zhao

Affiliations

Aude I. Segaliny: Amberstone Biosciences, Inc.
Jayapriya Jayaraman: Department of Biomedical Engineering, University of California, Irvine
Xiaoming Chen: Amberstone Biosciences, Inc.
Jonathan Chong: Amberstone Biosciences, Inc.
Ryan Luxon: Amberstone Biosciences, Inc.
Audrey Fung: Amberstone Biosciences, Inc.
Qiwei Fu: Amberstone Biosciences, Inc.
Xianzhi Jiang: Amberstone Biosciences, Inc.
Rodrigo Rivera: Amberstone Biosciences, Inc.
Xiaoya Ma: Amberstone Biosciences, Inc.
Ci Ren: Amberstone Biosciences, Inc.
Jan Zimak: Department of Pharmaceutical Sciences, University of California, Irvine
Per Niklas Hedde: Department of Biomedical Engineering, University of California, Irvine
Yonglei Shang: Amberstone Biosciences, Inc.
George Wu: Amberstone Biosciences, Inc.
Weian Zhao: Department of Biomedical Engineering, University of California, Irvine

DOI: https://doi.org/10.1038/s42003-023-04746-w
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 14

Abstract

Read online

A single-cell based bispecific antibody (BsAb) discovery pipeline, based on a microfluidics droplets generation and sorting systems, has the potential to speed up the discovery and development of functional antibodies such as BsAb therapeutics.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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