Clinical Ophthalmology (Jun 2022)
Real-World Experience with Intracapsular Administration of Dexamethasone Intraocular Suspension 9% for Control of Postoperative Inflammation
Abstract
Cathleen McCabe,1 Priya Desai,2 Lisa Nijm,3 Robert Osher,4 Robert Weinstock5 1The Eye Associates; Eye Health America, Sarasota Memorial Hospital, Sarasota, FL, USA; 2Matossian Eye Associates, Pennington, NJ, USA; 3Warrenville Eye Care and LASIK Center, Northwestern Medicine, Warrenville, IL, USA; 4Cincinnati Eye Institute, University of Cincinnati, Cincinnati, OH, USA; 5The Eye Institute of West Florida, Weinstock Laser Eye Center, Largo, FL, USACorrespondence: Cathleen McCabe, The Eye Associates; Eye Health America, Sarasota Memorial Hospital, Sarasota, FL, USA, Tel +1 941 792-2020, Email [email protected]: Corticosteroids and non-steroidal anti-inflammatory drugs are commonly used prophylactically to control inflammation after ocular surgery. When prescribed as eye drops, as has been longstanding tradition, anti-inflammatory success is out of surgeons’ hands, dependent on patient compliance and proper instillation technique. Sustained-release, intraoperatively administered anti-inflammatory drugs are emerging as another option. DEXYCU (dexamethasone intraocular suspension) 9% is the first and only intraocular corticosteroid FDA-approved for postoperative inflammation, whose sustained-release formulation provides a high initial release of drug, followed by a gradual tapering. Administration of the drug directly into the capsular bag following cataract surgery enables reliable placement proximal to target tissues, ensuring surgeon control and visibility of delivery, safety, and efficiency. This technique also minimizes contact with metabolically active tissues such as the corneal endothelium, iris, and ciliary body. In this paper, we review the available literature on dexamethasone intraocular suspension and summarize surgeons’ consensus on best practices for intracapsular administration.Keywords: cataract, corticosteroids, inflammation, technique
