Communications Biology (Nov 2022)
Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey
- Gabriella Worwa,
- Timothy K. Cooper,
- Steven Yeh,
- Jessica G. Shantha,
- Amanda M. W. Hischak,
- Sarah E. Klim,
- Russell Byrum,
- Jonathan R. Kurtz,
- Scott M. Anthony,
- Nina M. Aiosa,
- Danny Ragland,
- Ji Hyun Lee,
- Marisa St. Claire,
- Carl Davis,
- Rafi Ahmed,
- Michael R. Holbrook,
- Jens H. Kuhn,
- Erica Ollmann Saphire,
- Ian Crozier
Affiliations
- Gabriella Worwa
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Timothy K. Cooper
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Steven Yeh
- Emory Eye Center, Emory University
- Jessica G. Shantha
- Emory Eye Center, Emory University
- Amanda M. W. Hischak
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Sarah E. Klim
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Russell Byrum
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Jonathan R. Kurtz
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Scott M. Anthony
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Nina M. Aiosa
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Danny Ragland
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Ji Hyun Lee
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Marisa St. Claire
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Carl Davis
- Emory Vaccine Center, Emory University
- Rafi Ahmed
- Emory Vaccine Center, Emory University
- Michael R. Holbrook
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Jens H. Kuhn
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- Erica Ollmann Saphire
- Center for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology
- Ian Crozier
- Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick
- DOI
- https://doi.org/10.1038/s42003-022-04158-2
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 10
Abstract
Deep characterization of uveitis in a rhesus monkey confirms Ebola virus RNA persistence is associated with severe immunopathology in the eye, with broader implications for the prevention and treatment of sight-threatening uveitis in human survivors of Ebola virus.
