Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Abstract

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pathway inhibitors.

Keywords

• chemical diversity
• diversity-oriented
• hedgehog pathway
• inhibitor
• Sant-75
• synthesis