DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis

Acta Pharmaceutica Sinica B. 2015;5(3):188-193 DOI 10.1016/j.apsb.2015.01.011

 

Journal Homepage

Journal Title: Acta Pharmaceutica Sinica B

ISSN: 2211-3835 (Print); 2211-3843 (Online)

Publisher: Elsevier

Society/Institution: Insititute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association

LCC Subject Category: Medicine: Therapeutics. Pharmacology

Country of publisher: Netherlands

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Mingquan Sha (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China)
Genxiang Mao (Zhejiang Provincial Key Laboratory of Geriatrics & Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou 310013, China)
Guofu Wang (Zhejiang Provincial Key Laboratory of Geriatrics & Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou 310013, China)
Yufeng Chen (Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China)
Xiaojian Wu (Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China)
Zhen Wang (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 19 weeks

 

Abstract | Full Text

EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation, metastasis and poor prognosis. Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer. 3-Deazaneplanocin A (DZNep), as an EZH2 inhibitor, can suppress cancer cell growth. However, the anti-cancer role of DZNep in colon cancer cells has been rarely studied. In this study, we demonstrate that DZNep can inhibit the growth and survival of colon cancer HCT116 cells by inducing cellular senescence and apoptosis. The study provides a novel view of anti-cancer mechanisms of DZNep in human colon cancer cells.