DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis

Mingquan Sha; Genxiang Mao; Guofu Wang; Yufeng Chen; Xiaojian Wu; Zhen Wang

doi:10.1016/j.apsb.2015.01.011

Acta Pharmaceutica Sinica B (May 2015)

DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis

Mingquan Sha,
Genxiang Mao,
Guofu Wang,
Yufeng Chen,
Xiaojian Wu,
Zhen Wang

Affiliations

Mingquan Sha: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Genxiang Mao: Zhejiang Provincial Key Laboratory of Geriatrics & Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou 310013, China
Guofu Wang: Zhejiang Provincial Key Laboratory of Geriatrics & Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou 310013, China
Yufeng Chen: Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China
Xiaojian Wu: Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China
Zhen Wang: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

DOI: https://doi.org/10.1016/j.apsb.2015.01.011
Journal volume & issue: Vol. 5, no. 3
pp. 188 – 193

Abstract

Read online

EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation, metastasis and poor prognosis. Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer. 3-Deazaneplanocin A (DZNep), as an EZH2 inhibitor, can suppress cancer cell growth. However, the anti-cancer role of DZNep in colon cancer cells has been rarely studied. In this study, we demonstrate that DZNep can inhibit the growth and survival of colon cancer HCT116 cells by inducing cellular senescence and apoptosis. The study provides a novel view of anti-cancer mechanisms of DZNep in human colon cancer cells.

Published in Acta Pharmaceutica Sinica B

ISSN: 2211-3835 (Print); 2211-3843 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/acta-pharmaceutica-sinica-b

About the journal

Abstract

Keywords