Nature Communications (Nov 2019)
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
- Raymond Noordam,
- Maxime M. Bos,
- Heming Wang,
- Thomas W. Winkler,
- Amy R. Bentley,
- Tuomas O. Kilpeläinen,
- Paul S. de Vries,
- Yun Ju Sung,
- Karen Schwander,
- Brian E. Cade,
- Alisa Manning,
- Hugues Aschard,
- Michael R. Brown,
- Han Chen,
- Nora Franceschini,
- Solomon K. Musani,
- Melissa Richard,
- Dina Vojinovic,
- Stella Aslibekyan,
- Traci M. Bartz,
- Lisa de las Fuentes,
- Mary Feitosa,
- Andrea R. Horimoto,
- Marjan Ilkov,
- Minjung Kho,
- Aldi Kraja,
- Changwei Li,
- Elise Lim,
- Yongmei Liu,
- Dennis O. Mook-Kanamori,
- Tuomo Rankinen,
- Salman M. Tajuddin,
- Ashley van der Spek,
- Zhe Wang,
- Jonathan Marten,
- Vincent Laville,
- Maris Alver,
- Evangelos Evangelou,
- Maria E. Graff,
- Meian He,
- Brigitte Kühnel,
- Leo-Pekka Lyytikäinen,
- Pedro Marques-Vidal,
- Ilja M. Nolte,
- Nicholette D. Palmer,
- Rainer Rauramaa,
- Xiao-Ou Shu,
- Harold Snieder,
- Stefan Weiss,
- Wanqing Wen,
- Lisa R. Yanek,
- Correa Adolfo,
- Christie Ballantyne,
- Larry Bielak,
- Nienke R. Biermasz,
- Eric Boerwinkle,
- Niki Dimou,
- Gudny Eiriksdottir,
- Chuan Gao,
- Sina A. Gharib,
- Daniel J. Gottlieb,
- José Haba-Rubio,
- Tamara B. Harris,
- Sami Heikkinen,
- Raphaël Heinzer,
- James E. Hixson,
- Georg Homuth,
- M. Arfan Ikram,
- Pirjo Komulainen,
- Jose E. Krieger,
- Jiwon Lee,
- Jingmin Liu,
- Kurt K. Lohman,
- Annemarie I. Luik,
- Reedik Mägi,
- Lisa W. Martin,
- Thomas Meitinger,
- Andres Metspalu,
- Yuri Milaneschi,
- Mike A. Nalls,
- Jeff O’Connell,
- Annette Peters,
- Patricia Peyser,
- Olli T. Raitakari,
- Alex P. Reiner,
- Patrick C. N. Rensen,
- Treva K. Rice,
- Stephen S. Rich,
- Till Roenneberg,
- Jerome I. Rotter,
- Pamela J. Schreiner,
- James Shikany,
- Stephen S. Sidney,
- Mario Sims,
- Colleen M. Sitlani,
- Tamar Sofer,
- Konstantin Strauch,
- Morris A. Swertz,
- Kent D. Taylor,
- André G. Uitterlinden,
- Cornelia M. van Duijn,
- Henry Völzke,
- Melanie Waldenberger,
- Robert B. Wallance,
- Ko Willems van Dijk,
- Caizheng Yu,
- Alan B. Zonderman,
- Diane M. Becker,
- Paul Elliott,
- Tõnu Esko,
- Christian Gieger,
- Hans J. Grabe,
- Timo A. Lakka,
- Terho Lehtimäki,
- Kari E. North,
- Brenda W. J. H. Penninx,
- Peter Vollenweider,
- Lynne E. Wagenknecht,
- Tangchun Wu,
- Yong-Bing Xiang,
- Wei Zheng,
- Donna K. Arnett,
- Claude Bouchard,
- Michele K. Evans,
- Vilmundur Gudnason,
- Sharon Kardia,
- Tanika N. Kelly,
- Stephen B. Kritchevsky,
- Ruth J. F. Loos,
- Alexandre C. Pereira,
- Mike Province,
- Bruce M. Psaty,
- Charles Rotimi,
- Xiaofeng Zhu,
- Najaf Amin,
- L. Adrienne Cupples,
- Myriam Fornage,
- Ervin F. Fox,
- Xiuqing Guo,
- W. James Gauderman,
- Kenneth Rice,
- Charles Kooperberg,
- Patricia B. Munroe,
- Ching-Ti Liu,
- Alanna C. Morrison,
- Dabeeru C. Rao,
- Diana van Heemst,
- Susan Redline
Affiliations
- Raymond Noordam
- Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center
- Maxime M. Bos
- Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center
- Heming Wang
- Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital
- Thomas W. Winkler
- Department of Genetic Epidemiology, University of Regensburg
- Amy R. Bentley
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Tuomas O. Kilpeläinen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Paul S. de Vries
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Yun Ju Sung
- Division of Biostatistics, Washington University School of Medicine
- Karen Schwander
- Division of Biostatistics, Washington University School of Medicine
- Brian E. Cade
- Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital
- Alisa Manning
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital
- Hugues Aschard
- Department of Epidemiology, Harvard School of Public Health
- Michael R. Brown
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Han Chen
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Nora Franceschini
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Solomon K. Musani
- Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center
- Melissa Richard
- Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston
- Dina Vojinovic
- Department of Epidemiology, Erasmus University Medical Center
- Stella Aslibekyan
- Department of Epidemiology, University of Alabama at Birmingham
- Traci M. Bartz
- Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington
- Lisa de las Fuentes
- Division of Biostatistics, Washington University School of Medicine
- Mary Feitosa
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Andrea R. Horimoto
- Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School
- Marjan Ilkov
- Icelandic Heart Association
- Minjung Kho
- Department of Epidemiology, School of Public Health, University of Michigan
- Aldi Kraja
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Changwei Li
- Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health
- Elise Lim
- Department of Biostatistics, Boston University School of Public Health
- Yongmei Liu
- Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences
- Dennis O. Mook-Kanamori
- Department of Clinical Epidemiology, Leiden University Medical Center
- Tuomo Rankinen
- Human Genomics Laboratory, Pennington Biomedical Research Center
- Salman M. Tajuddin
- Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Ashley van der Spek
- Department of Epidemiology, Erasmus University Medical Center
- Zhe Wang
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Jonathan Marten
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Vincent Laville
- Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur
- Maris Alver
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Evangelos Evangelou
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Maria E. Graff
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Meian He
- Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology
- Brigitte Kühnel
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories
- Pedro Marques-Vidal
- Medicine, Internal Medicine, Lausanne University Hospital
- Ilja M. Nolte
- University of Groningen, University Medical Center Groningen, Department of Epidemiology
- Nicholette D. Palmer
- Biochemistry, Wake Forest School of Medicine
- Rainer Rauramaa
- Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine
- Xiao-Ou Shu
- Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine
- Harold Snieder
- University of Groningen, University Medical Center Groningen, Department of Epidemiology
- Stefan Weiss
- Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald
- Wanqing Wen
- Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine
- Lisa R. Yanek
- Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine
- Correa Adolfo
- Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center
- Christie Ballantyne
- Section of Cardiovascular Research, Baylor College of Medicine
- Larry Bielak
- Department of Epidemiology, School of Public Health, University of Michigan
- Nienke R. Biermasz
- Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center
- Eric Boerwinkle
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Niki Dimou
- Department of Hygiene and Epidemiology, University of Ioannina Medical School
- Gudny Eiriksdottir
- Icelandic Heart Association
- Chuan Gao
- Molecular Genetics and Genomics Program, Wake Forest School of Medicine
- Sina A. Gharib
- Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Medicine, University of Washington
- Daniel J. Gottlieb
- Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital
- José Haba-Rubio
- Medicine, Sleep Laboratory, Lausanne University Hospital
- Tamara B. Harris
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Sami Heikkinen
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
- Raphaël Heinzer
- Medicine, Sleep Laboratory, Lausanne University Hospital
- James E. Hixson
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Georg Homuth
- Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald
- M. Arfan Ikram
- Department of Epidemiology, Erasmus University Medical Center
- Pirjo Komulainen
- Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine
- Jose E. Krieger
- Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School
- Jiwon Lee
- Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital
- Jingmin Liu
- Fred Hutchinson Cancer Research Center, University of Washington School of Public Health
- Kurt K. Lohman
- Public Health Sciences, Biostatistical Sciences, Wake Forest University Health Sciences
- Annemarie I. Luik
- Department of Epidemiology, Erasmus University Medical Center
- Reedik Mägi
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Lisa W. Martin
- Cardiology, School of Medicine and Health Sciences, George Washington University
- Thomas Meitinger
- Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Andres Metspalu
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Yuri Milaneschi
- Cardiology, School of Medicine and Health Sciences, George Washington University
- Mike A. Nalls
- Laboratory of Neurogenetics, National Institute on Aging
- Jeff O’Connell
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Annette Peters
- Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Patricia Peyser
- Department of Epidemiology, School of Public Health, University of Michigan
- Olli T. Raitakari
- Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
- Alex P. Reiner
- Fred Hutchinson Cancer Research Center, University of Washington School of Public Health
- Patrick C. N. Rensen
- Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center
- Treva K. Rice
- Division of Biostatistics, Washington University School of Medicine
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia
- Till Roenneberg
- Institute of Medical Psychology, Ludwig-Maximilians-Universitat Munchen
- Jerome I. Rotter
- Genomic Outcomes, Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center
- Pamela J. Schreiner
- Division of Epidemiology & Community Health, School of Public Health, University of Minnesota
- James Shikany
- Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham
- Stephen S. Sidney
- Division of Research, Kaiser Permanente Northern California
- Mario Sims
- Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center
- Colleen M. Sitlani
- Cardiovascular Health Research Unit, Medicine, University of Washington
- Tamar Sofer
- Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital
- Konstantin Strauch
- Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Morris A. Swertz
- University of Groningen, University Medical Center Groningen, Department of Genetics
- Kent D. Taylor
- Genomic Outcomes, Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center
- André G. Uitterlinden
- Department of Epidemiology, Erasmus University Medical Center
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus University Medical Center
- Henry Völzke
- Institute for Community Medicine, University Medicine Greifswald
- Melanie Waldenberger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Robert B. Wallance
- Department of Epidemiology, University of Iowa College of Public Health
- Ko Willems van Dijk
- Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center
- Caizheng Yu
- Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology
- Alan B. Zonderman
- Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Diane M. Becker
- Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine
- Paul Elliott
- Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu
- Tõnu Esko
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Christian Gieger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Hans J. Grabe
- Department Psychiatry and Psychotherapy, University Medicine Greifswald
- Timo A. Lakka
- Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Kari E. North
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Brenda W. J. H. Penninx
- Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit
- Peter Vollenweider
- Medicine, Internal Medicine, Lausanne University Hospital
- Lynne E. Wagenknecht
- Public Health Sciences, Wake Forest School of Medicine
- Tangchun Wu
- Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology
- Yong-Bing Xiang
- SKLORG & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine
- Donna K. Arnett
- Dean’s Office, University of Kentucky College of Public Health
- Claude Bouchard
- Human Genomics Laboratory, Pennington Biomedical Research Center
- Michele K. Evans
- Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Vilmundur Gudnason
- Icelandic Heart Association
- Sharon Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Tanika N. Kelly
- Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Stephen B. Kritchevsky
- Sticht Center for Healthy Aging and Rehabilitation, Gerontology and Geriatric Medicine, Wake Forest School of Medicine
- Ruth J. F. Loos
- The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai
- Alexandre C. Pereira
- Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School
- Mike Province
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington
- Charles Rotimi
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Xiaofeng Zhu
- Department of Population Quantitative and Health Sciences, Case Western Reserve University
- Najaf Amin
- Department of Epidemiology, Erasmus University Medical Center
- L. Adrienne Cupples
- Department of Biostatistics, Boston University School of Public Health
- Myriam Fornage
- Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston
- Ervin F. Fox
- Cardiology, Medicine, University of Mississippi Medical Center
- Xiuqing Guo
- Genomic Outcomes, Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center
- W. James Gauderman
- Biostatistics, Preventive Medicine, University of Southern California
- Kenneth Rice
- Department of Biostatistics, University of Washington
- Charles Kooperberg
- Fred Hutchinson Cancer Research Center, University of Washington School of Public Health
- Patricia B. Munroe
- Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Ching-Ti Liu
- Department of Biostatistics, Boston University School of Public Health
- Alanna C. Morrison
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Dabeeru C. Rao
- Division of Biostatistics, Washington University School of Medicine
- Diana van Heemst
- Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center
- Susan Redline
- Division of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital
- DOI
- https://doi.org/10.1038/s41467-019-12958-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Sleep duration is associated with an adverse lipid profile. Here, the authors perform genome-wide gene-by-sleep interaction analysis and find 49 previously unreported lipid loci when considering short or long total sleep time.
