Neurobiology of Disease (Mar 2025)
Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to Parkinson's and Lewy Body diseases: An exploratory study
- Claudio Del Percio,
- Roberta Lizio,
- Susanna Lopez,
- Giuseppe Noce,
- Dharmendra Jakhar,
- Matteo Carpi,
- Burcu Bölükbaş,
- Andrea Soricelli,
- Marco Salvatore,
- Bahar Güntekin,
- Görsev Yener,
- Federico Massa,
- Dario Arnaldi,
- Francesco Famà,
- Matteo Pardini,
- Raffaele Ferri,
- Michele Salerni,
- Bartolo Lanuzza,
- Fabrizio Stocchi,
- Laura Vacca,
- Chiara Coletti,
- Moira Marizzoni,
- John Paul Taylor,
- Lutfu Hanoğlu,
- Nesrin Helvacı Yılmaz,
- İlayda Kıyı,
- Yağmur Özbek-İşbitiren,
- Giovanni B. Frisoni,
- Sofia Cuoco,
- Paolo Barone,
- Anita D'Anselmo,
- Laura Bonanni,
- Roberta Biundo,
- Fabrizia D'Antonio,
- Giuseppe Bruno,
- Franco Giubilei,
- Francesca De Pandis,
- Rossella Rotondo,
- Angelo Antonini,
- Claudio Babiloni
Affiliations
- Claudio Del Percio
- Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy
- Roberta Lizio
- Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy; Oasi Research Institute – IRCCS, Troina, Italy; Corresponding author at: Department of Physiology and Pharmacology ''V. Erspamer'', Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.
- Susanna Lopez
- Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy
- Giuseppe Noce
- IRCCS Synlab SDN, Naples, Italy
- Dharmendra Jakhar
- Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy
- Matteo Carpi
- Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy
- Burcu Bölükbaş
- Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy
- Andrea Soricelli
- IRCCS Synlab SDN, Naples, Italy; Department of Medical, Movement and Well-being Sciences, University of Naples Parthenope, Naples, Italy
- Marco Salvatore
- IRCCS Synlab SDN, Naples, Italy
- Bahar Güntekin
- Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey; Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Turkey
- Görsev Yener
- Department of Neurology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey; IBG: International Biomedicine and Genome Center, Izmir, Turkey
- Federico Massa
- Dipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-infantili (DiNOGMI), Università di Genova, Italy; Clinica neurologica, IRCCS Ospedale Policlinico San Martino, Genova, Italy
- Dario Arnaldi
- Dipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-infantili (DiNOGMI), Università di Genova, Italy; Neurofisiopatologia, IRCCS Ospedale Policlinico San Martino, Genova, Italy
- Francesco Famà
- Dipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-infantili (DiNOGMI), Università di Genova, Italy; Neurofisiopatologia, IRCCS Ospedale Policlinico San Martino, Genova, Italy
- Matteo Pardini
- Dipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-infantili (DiNOGMI), Università di Genova, Italy; Neurofisiopatologia, IRCCS Ospedale Policlinico San Martino, Genova, Italy
- Raffaele Ferri
- Oasi Research Institute – IRCCS, Troina, Italy
- Michele Salerni
- Oasi Research Institute – IRCCS, Troina, Italy
- Bartolo Lanuzza
- Oasi Research Institute – IRCCS, Troina, Italy
- Fabrizio Stocchi
- IRCCS San Raffaele, Rome, Italy
- Laura Vacca
- IRCCS San Raffaele, Rome, Italy
- Chiara Coletti
- IRCCS San Raffaele, Rome, Italy
- Moira Marizzoni
- Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
- John Paul Taylor
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, UK
- Lutfu Hanoğlu
- Department of Neurology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey
- Nesrin Helvacı Yılmaz
- Medipol University Istanbul Parkinson's Disease and Movement Disorders Center (PARMER), Istanbul, Turkey
- İlayda Kıyı
- Health Sciences Institute, Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey
- Yağmur Özbek-İşbitiren
- Health Sciences Institute, Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey
- Giovanni B. Frisoni
- Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE – Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland
- Sofia Cuoco
- Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Neuroscience Section, University of Salerno, Baronissi, Italy
- Paolo Barone
- Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Neuroscience Section, University of Salerno, Baronissi, Italy
- Anita D'Anselmo
- Department of Aging Medicine and Sciences, University “G. d'Annunzio” of Chieti-Pescara, Italy
- Laura Bonanni
- Department of Aging Medicine and Sciences, University “G. d'Annunzio” of Chieti-Pescara, Italy
- Roberta Biundo
- Department of Neuroscience, University of Padua, Padua, PD, Italy
- Fabrizia D'Antonio
- Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy
- Giuseppe Bruno
- Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy
- Franco Giubilei
- Department of Neuroscience, Mental Health, and Sensory Organs, Sapienza University of Rome, Rome, Italy
- Francesca De Pandis
- Department of Human Sciences and Promotion of the Quality of Life, University San Raffaele Roma, Italy; Hospital San Raffaele Cassino, Cassino, FR, Italy
- Rossella Rotondo
- Hospital San Raffaele Cassino, Cassino, FR, Italy
- Angelo Antonini
- Department of Neuroscience, University of Padua, Padua, PD, Italy
- Claudio Babiloni
- Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy; Hospital San Raffaele Cassino, Cassino, FR, Italy
- Journal volume & issue
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Vol. 206
p. 106807
Abstract
Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are more prevalent in males than females. Furthermore, they typically showed abnormally high delta (< 4 Hz) and low alpha (8–10 Hz) rhythms from resting-state electroencephalographic (rsEEG) activity. Here, we hypothesized that those abnormalities may depend on the patient's sex.An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 49; 24 females), PDD (N = 39; 13 females), and DLB (N = 38; 15 females) participants. Each group was stratified into matched female and male subgroups. The rsEEG rhythms were investigated across the individual rsEEG delta, theta, and alpha frequency bands based on the individual alpha frequency peak. The eLORETA freeware was used to estimate cortical rsEEG sources.In the Healthy group, widespread rsEEG alpha source activities were greater in the females than in the males. In the PDD group, widespread rsEEG delta source activities were lower and widespread rsEEG alpha source activities were greater in the females than in the males. In the DLB group, central-parietal rsEEG delta source activities were lower, and posterior rsEEG alpha source activities were greater in the females than in the males.These results suggest sex-dependent hormonal modulation of neuroprotective-compensatory neurophysiological mechanisms in PDD and DLB patients underlying the generation of rsEEG delta and alpha rhythms, which should be considered in the treatment of vigilance dysregulation in those patients.
