Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear

Zhaowei Chen; Jiankai Lu; Changjie Zhang; Isaac Hsia; Xinheng Yu; Leo Marecki; Eric Marecki; Mohammadnabi Asmani; Shilpa Jain; Sriram Neelamegham; Ruogang Zhao

doi:10.1038/s41467-019-10067-6

Nature Communications (May 2019)

Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear

Zhaowei Chen,
Jiankai Lu,
Changjie Zhang,
Isaac Hsia,
Xinheng Yu,
Leo Marecki,
Eric Marecki,
Mohammadnabi Asmani,
Shilpa Jain,
Sriram Neelamegham,
Ruogang Zhao

Affiliations

Zhaowei Chen: Department of Biomedical Engineering, State University of New York at Buffalo
Jiankai Lu: Department of Biomedical Engineering, State University of New York at Buffalo
Changjie Zhang: Department of Chemical and Biological Engineering and Clinical & Translational Research Center, State University of New York at Buffalo
Isaac Hsia: Department of Biomedical Engineering, State University of New York at Buffalo
Xinheng Yu: Department of Chemical and Biological Engineering and Clinical & Translational Research Center, State University of New York at Buffalo
Leo Marecki: Department of Biomedical Engineering, State University of New York at Buffalo
Eric Marecki: Department of Biomedical Engineering, State University of New York at Buffalo
Mohammadnabi Asmani: Department of Biomedical Engineering, State University of New York at Buffalo
Shilpa Jain: Hemophilia Center of Western New York, Department of Pediatrics, Division of Pediatric Hematology-Oncology, John R. Oishei Children’s Hospital of Buffalo
Sriram Neelamegham: Department of Chemical and Biological Engineering and Clinical & Translational Research Center, State University of New York at Buffalo
Ruogang Zhao: Department of Biomedical Engineering, State University of New York at Buffalo

DOI: https://doi.org/10.1038/s41467-019-10067-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Blood clotting is a complex process involving platelet adhesion and clot stiffening. Here the authors present a microfluidic system to recapitulate the dynamic changes in clot mechanics under physiological shear.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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