Imaging technologies in the differential diagnosis and follow-up of brown tumor in primary hyperparathyroidism: Case report and review of the literature
Davide Diacinti,
Cristiana Cipriani,
Federica Biamonte,
Jessica Pepe,
Luciano Colangelo,
Endi Kripa,
Antonio Iannacone,
Martina Orlandi,
Vito Guarnieri,
Daniele Diacinti,
Salvatore Minisola
Affiliations
Davide Diacinti
Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Italy; Department of Diagnostic and Molecular Imaging, Radiology and Radiotherapy, PTV Foundation “Tor Vergata” University, Rome, Italy
Cristiana Cipriani
Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Italy; Corresponding author.
Federica Biamonte
Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Italy; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Italy
Jessica Pepe
Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Italy
Luciano Colangelo
Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Italy; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Italy
Endi Kripa
Department of Radiological Sciences, Oncology and Anatomy-Pathology, Sapienza University of Rome, Italy
Antonio Iannacone
Department of Radiological Sciences, Oncology and Anatomy-Pathology, Sapienza University of Rome, Italy
Martina Orlandi
Department of Radiological Sciences, Oncology and Anatomy-Pathology, Sapienza University of Rome, Italy
Vito Guarnieri
Division of Medical Genetics, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Foggia, Italy
Daniele Diacinti
Department of Radiological Sciences, Oncology and Anatomy-Pathology, Sapienza University of Rome, Italy
Salvatore Minisola
Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Italy
Brown tumors are osteolytic lesions associated with hyperparathyroidism (HPT). They may involve various skeletal segments, but rarely the cranio-facial bones. We report a case of a young boy with a swelling of the jaw secondary to a brown tumor presenting as the first manifestation of primary HPT (PHPT). He was found to have brown tumor located in the skull, as well. Different imaging technologies were employed for the diagnosis and follow-up after parathyroidectomy. We enclose a review of the literature on the employment of such imaging technologies in the differential diagnosis of osteolytic lesions. A multidisciplinary approach comprising clinical, laboratory and imaging findings is essential for the differential diagnosis of brown tumor in PHPT.
