Nature Communications (Sep 2019)

Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis

  • Gregory M. I. Redpath,
  • Manuela Ecker,
  • Natasha Kapoor-Kaushik,
  • Haig Vartoukian,
  • Michael Carnell,
  • Daryan Kempe,
  • Maté Biro,
  • Nicholas Ariotti,
  • Jérémie Rossy

DOI
https://doi.org/10.1038/s41467-019-12352-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Internalized receptors are recycled back to the cell surface, but their precise mechanisms are unclear. Here, the authors show that the flotillin membrane proteins may regulate the transfer of internalized T cell receptors into Rab5 and Rab11-positive endosomes to support its rapid recycling.