Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation

Audrey Chabrat; Guillaume Brisson; Hélène Doucet-Beaupré; Charleen Salesse; Marcos Schaan Profes; Axelle Dovonou; Cléophace Akitegetse; Julien Charest; Suzanne Lemstra; Daniel Côté; R. Jeroen Pasterkamp; Monica I. Abrudan; Emmanouil Metzakopian; Siew-Lan Ang; Martin Lévesque

doi:10.1038/s41467-017-01042-0

Nature Communications (Oct 2017)

Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation

Audrey Chabrat,
Guillaume Brisson,
Hélène Doucet-Beaupré,
Charleen Salesse,
Marcos Schaan Profes,
Axelle Dovonou,
Cléophace Akitegetse,
Julien Charest,
Suzanne Lemstra,
Daniel Côté,
R. Jeroen Pasterkamp,
Monica I. Abrudan,
Emmanouil Metzakopian,
Siew-Lan Ang,
Martin Lévesque

Affiliations

Audrey Chabrat: Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval
Guillaume Brisson: Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval
Hélène Doucet-Beaupré: Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval
Charleen Salesse: Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval
Marcos Schaan Profes: Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval
Axelle Dovonou: Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval
Cléophace Akitegetse: Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval
Julien Charest: Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval
Suzanne Lemstra: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht
Daniel Côté: CERVO Brain Research Centre, 2601, chemin de la Canardière
R. Jeroen Pasterkamp: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht
Monica I. Abrudan: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Emmanouil Metzakopian: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Siew-Lan Ang: The Francis Crick Institute
Martin Lévesque: Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval

DOI: https://doi.org/10.1038/s41467-017-01042-0
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Midbrain dopaminergic neurons (mDAs) in the VTA and SNpc project to different regions and form distinct circuits. Here the authors show that transcription factors Lmx1a, Lmx1b, and Otx2 control the axon guidance of mDAs and the segregation of mesolimbic and nigrostriatal dopaminergic pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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