P6.3 PLATELET ACTIVITY IN TEEN GIRLS WITH PRIMARY ARTERIAL HYPERTENSION

Abstract

Objective: Primary arterial hypertension (PAH) – a multifactorial disease. Its etiology, especially in children, still causes a lot of questions and diagnostic tests are not common in clinical practice. Even less is known of the variation in platelet activity in adolescents with PAH, this study was the assessment of platelet activity in healthy subjects and patients with PAH in groups of 17–18 year old girls. Materials and methods: Platelet functional activity was determined by flow cytometry. Platelets used to identify the three antibodies: CD42a (GP IX), CD41a (GP IIb) and CD61 (GP IIIa) and assessing the activity of select PAC-1 antibody that binds specifically to activated GPIIb / IIIa complex. Through 2008–2013 years platelet activity was assessed 31 with primary arterial hypertension 17–18 year old girl (case group) and 33 healthy girls (control group). A statistical analysis was done and the significance assessed by a X-square test. The statistical difference was considered significant if the p value was below 0.05. Results: Teen girls with PAH group hasn‘t statistically significantly more platelets (both percentage and absolute terms) that joined the PAC-1 antibody. We can not say that suffering from PAH girls, have an increased platelet activity. Conclusions: The girls, who have PAH, functional platelet activity has not differ from healthy. But perhaps it should be more research sample, and it should involve risk factors.

Keywords

• Primary arterial hypertension
• platelet activity