Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function

Jian Tan; Duan Ni; Jibran Abdul Wali; Darren Anthony Cox; Gabriela Veronica Pinget; Jemma Taitz; Claire Immediato Daïen; Alistair Senior; Mark Norman Read; Stephen James Simpson; Nicholas Jonathan Cole King; Laurence Macia

iScience (Aug 2021)

Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function

Jian Tan,
Duan Ni,
Jibran Abdul Wali,
Darren Anthony Cox,
Gabriela Veronica Pinget,
Jemma Taitz,
Claire Immediato Daïen,
Alistair Senior,
Mark Norman Read,
Stephen James Simpson,
Nicholas Jonathan Cole King,
Laurence Macia

Affiliations

Jian Tan: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia
Duan Ni: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia
Jibran Abdul Wali: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia
Darren Anthony Cox: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Pathology School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia
Gabriela Veronica Pinget: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia
Jemma Taitz: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia
Claire Immediato Daïen: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; CHRU Montpellier, Département de Rhumatologie, Montpellier FRANCE & University of Montpellier, PhyMedExp, INSERM, CNRS UMR, Montpellier, France
Alistair Senior: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; School of Computer Science, Faculty of Engineering, University of Sydney, Sydney, NSW, Australia; School of Mathematics and Statistics, University of Sydney, Sydney, NSW, Australia
Mark Norman Read: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; School of Computer Science, Faculty of Engineering, University of Sydney, Sydney, NSW, Australia; The Westmead Initiative, Faculty of Engineering, The University of Sydney, Sydney, NSW, Australia
Stephen James Simpson: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia
Nicholas Jonathan Cole King: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Pathology School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Sydney Cytometry, The University of Sydney and The Centenary Institute, Sydney, NSW, Australia; Corresponding author
Laurence Macia: Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Corresponding author

Journal volume & issue: Vol. 24, no. 8
p. 102835

Abstract

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Summary: While diet modulates immunity, its impact on B cell ontogeny remains unclear. Using mixture modeling, a large-scale isocaloric dietary cohort mouse study identified carbohydrate as a major driver of B cell development and function. Increasing dietary carbohydrate increased B cell proportions in spleen, mesenteric lymph node and Peyer’s patches, and increased antigen-specific immunoglobulin G production after immunization. This was linked to increased B lymphopoiesis in the bone marrow. Glucose promoted early B lymphopoiesis and higher total B lymphocyte numbers than fructose. It drove B cell development through glycolysis and oxidative phosphorylation, independently of fatty acid oxidation in vitro and reduced B cell apoptosis in early development via mTOR activation, independently of interleukin-7. Ours is the first comprehensive study showing the impact of macronutrients on B cell development and function. It shows the quantitative and qualitative interplay between dietary carbohydrate and B cells and argues for dietary modulation in B cell-targeting strategies.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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