RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression

Weipeng Mu; Noel S Murcia; Keriayn N Smith; Debashish U Menon; Della Yee; Terry Magnuson

doi:10.1093/g3journal/jkac082

G3: Genes, Genomes, Genetics (Apr 2022)

RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression

Weipeng Mu,
Noel S Murcia,
Keriayn N Smith,
Debashish U Menon,
Della Yee,
Terry Magnuson

Affiliations

Weipeng Mu: ORCiD; Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USA
Noel S Murcia: ORCiD; Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USA
Keriayn N Smith: ORCiD; Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USA
Debashish U Menon: ORCiD; Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USA
Della Yee: ORCiD; Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USA
Terry Magnuson: ORCiD; Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USA

DOI: https://doi.org/10.1093/g3journal/jkac082
Journal volume & issue: Vol. 12, no. 6

Abstract

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AbstractRBBP4 is a subunit of the chromatin remodeling complexes known as Polycomb repressive complex 2 and histone deacetylase 1/2-containing complexes. These complexes are responsible for histone H3 lysine 27 methylation and deacetylation, respectively. How RBBP4 modulates the functions of these complexes remains largely unknown. We generated viable Rbbp4Rbbp4

Published in G3: Genes, Genomes, Genetics

ISSN: 2160-1836 (Online)
Publisher: Oxford University Press
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Genetics
Website: https://academic.oup.com/g3journal

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