Nature Communications (Aug 2018)

Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

  • Wei Huang,
  • Yi Peng,
  • Janna Kiselar,
  • Xuan Zhao,
  • Aljawharah Albaqami,
  • Daniel Mendez,
  • Yinghua Chen,
  • Srinivas Chakravarthy,
  • Sayan Gupta,
  • Corie Ralston,
  • Hung-Ying Kao,
  • Mark R. Chance,
  • Sichun Yang

DOI
https://doi.org/10.1038/s41467-018-06034-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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The human estrogen receptor alpha (hERα) is a hormone-responsive transcription factor. Here the authors combine small-angle X-ray scattering, hydroxyl radical protein footprinting and computational modeling and show that multidomain hERα adopts an L-shaped boot-like architecture revealing a cross-talk between its DNA-binding domain and Ligand-binding domain.