Evaluation of Anti-Inflammatory Effect of Chicory Extract on Inflammatory Factors of Interleukin 8 and TNFα in Rats with Polycystic Ovary Syndrome

Abstract

Background & Objective: Polycystic ovary disease is an indicator of inflammatory factors caused by ovarian inflammation and an increase in the number of ovarian cysts. The aim of the present study was to investigate the effect of hydroalcoholic extract of chicory plant on inflammatory markers in polycystic ovary syndrome rats. Materials & Methods: In this study, adult female Wistar rats weighing 150-250 g were used and fed to the positive control group of metformin and negative control group via water gavage. At the end of blood sampling, serum levels of insulin, cholesterol, triglyceride and inflammatory factors interleukin-8 and TNFα were measured by ELISA. Results: The present study showed that 400 mg/kg abstract of chicory can significantly reduce sugar and insulin of blood and fat profile and inflammation factors IL8 and TNFα. Significance level was considered as p<0.05 Conclusion: Given the positive effect of chicory abstract on serum concentration of sugar and insulin hormone and fat profile and inflammation factors in the rats with PCOS, this composition can be used as an alternative drug for treating this disease.

Keywords

• polycystic ovary syndrome
• chicory
• tnfα
• il 8
• pcos