Molecules (Jun 2024)

Diterpenoids from the Aerial Parts of <i>Isodon serra</i> with Selective Cytotoxic Activity

  • Siqin Li,
  • Fang Liang,
  • Dongdong Huang,
  • Huanling Wu,
  • Xiaohua Tan,
  • Jiang Ma,
  • Caihong Wei,
  • Shixiong Wang,
  • Ziying Huang,
  • Guang Yang,
  • Xin He,
  • Ji Yang

DOI
https://doi.org/10.3390/molecules29122733
Journal volume & issue
Vol. 29, no. 12
p. 2733

Abstract

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Four new diterpenoids, isodosins A–D (1–4), together with nine known compounds (5–13) were isolated and identified from the aerial parts of Isodon serra (Maxim.) Hara. The structures of the new diterpenoids were elucidated based on the analysis of HR-ESI-MS data, 1D/2D-NMR-spectroscopic data, and electronic circular dichroism (ECD) calculations. Cytotoxicities of compounds 2, 3, 5, 6, and 9 against the HepG2 and H1975 cell lines were evaluated with the MTT assay. As a result, compounds 2, 3, and 6 revealed higher levels of cytotoxicity against HepG2 cells than against H1975 cells. Moreover, compund 6 demonstrated the most efficacy in inhibiting the proliferation of HepG2 cells, with an IC50 value of 41.13 ± 3.49 μM. This effect was achieved by inducing apoptosis in a dose-dependent manner. Furthermore, the relationships between the structures and activities of these compounds are briefly discussed.

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