Improving Riparin-A Dissolution through a Laponite Based Nanohybrid
Duanne Mendes Gomes,
Lyghia Maria Araújo Meirelles,
Paulo Monteiro Araujo,
Rayran Walter Ramos de Sousa,
Paulo Michel Pinheiro Ferreira,
Stanley Juan Chavez Gutierrez,
Maria das Graças Freire de Medeiros,
Fernanda Nervo Raffin
Affiliations
Duanne Mendes Gomes
Post Program on Pharmaceutical Sciences, Federal University of Piauí—UFPI, Teresina 64049-550, Piauí, Brazil
Lyghia Maria Araújo Meirelles
Department of Pharmacy, Federal University of Piauí—UFPI, Teresina 64049-550, Piauí, Brazil
Paulo Monteiro Araujo
Post Program on Pharmaceutical Sciences, Federal University of Piauí—UFPI, Teresina 64049-550, Piauí, Brazil
Rayran Walter Ramos de Sousa
Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí—UFPI, Teresina 64049-550, Piauí, Brazil
Paulo Michel Pinheiro Ferreira
Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí—UFPI, Teresina 64049-550, Piauí, Brazil
Stanley Juan Chavez Gutierrez
Post Program on Pharmaceutical Sciences, Federal University of Piauí—UFPI, Teresina 64049-550, Piauí, Brazil
Maria das Graças Freire de Medeiros
Post Program on Pharmaceutical Sciences, Federal University of Piauí—UFPI, Teresina 64049-550, Piauí, Brazil
Fernanda Nervo Raffin
Post—Program on Development and Technological Innovation in Medications, Federal University of Rio Grande do Norte—UFRN, Natal 59012-570, Rio Grande do Norte, Brazil
(1) Background: Riparin-A presents several pharmacological activities already elucidated, such as antimicrobial modulator, antileishmania, anxiolytic, anti-inflammatory, antinociceptive, and antioxidant. Even with important bioactive effects, the applicability of Riparin-A is limited due to its low solubility in water, impairing its dissolution in biological fluids. Thus, the objective of this study was to develop a nanohybrid based on Riparin-A and Laponite to obtain a better dissolution profile and evaluate its cytotoxic potential. (2) Methods: The formation of a hybrid system was highlighted by X-ray powder diffraction, infrared spectroscopy, and thermal analysis. Solubility, dissolution, and cytotoxicity studies were performed; (3) Results: An increase in the solubility and aqueous dissolution rate of Riparin-A was observed in the presence of clay. Diffractometric analysis of the hybrid system suggests the amorphization of Riparin-A, and thermal analyses indicated attenuation of decomposition and melting of the Riparin-A after interaction with clay. Furthermore, the nanosystem did not exhibit cytotoxic activity on normal and tumorigenic lines. (4) Conclusions: These results are promising for the development of the Riparin-A/Laponite nanosystem for therapeutic purposes, suggesting an increase in the range of possible routes of administration and bioavailability of this bioactive compound.
