Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

Son C. Le; Zhiguang Jia; Jianhan Chen; Huanghe Yang

doi:10.1038/s41467-019-11784-8

Nature Communications (Aug 2019)

Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

Son C. Le,
Zhiguang Jia,
Jianhan Chen,
Huanghe Yang

Affiliations

Son C. Le: Department of Biochemistry, Duke University Medical Center
Zhiguang Jia: Department of Chemistry, University of Massachusetts
Jianhan Chen: Department of Chemistry, University of Massachusetts
Huanghe Yang: Department of Biochemistry, Duke University Medical Center

DOI: https://doi.org/10.1038/s41467-019-11784-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability and muscle contraction. Here authors show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and desensitization via binding to a putative binding site.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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