Improved cerebral microbleeds detection using their magnetic signature on T2*-phase-contrast: A comparison study in a clinical setting

NeuroImage: Clinical. 2017;15:274-283

 

Journal Homepage

Journal Title: NeuroImage: Clinical

ISSN: 2213-1582 (Online)

Publisher: Elsevier

LCC Subject Category: Medicine: Medicine (General): Computer applications to medicine. Medical informatics | Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system

Country of publisher: Netherlands

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Takoua Kaaouana (Sorbonne Univ, UPMC Univ Paris 06, UM 75, ICM, F-75013 Paris, France; Inserm, U1127, ICM, F-75013 Paris, France; CNRS, UMR 7225, ICM, F-75013 Paris, France; ICM, Paris, France; Inria, Aramis project-team, Centre Paris-Rocquencourt, France; CATI, Paris, France; Corresponding author at: Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, UMR 7225 CNRS - UMRS 975 INSERM, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75013 Paris Cedex, France.)
Anne Bertrand (Sorbonne Univ, UPMC Univ Paris 06, UM 75, ICM, F-75013 Paris, France; Inserm, U1127, ICM, F-75013 Paris, France; CNRS, UMR 7225, ICM, F-75013 Paris, France; ICM, Paris, France; Inria, Aramis project-team, Centre Paris-Rocquencourt, France; Neuroradiology, CHRU Pitié Salpêtrière, Paris, France)
Fatma Ouamer (Neuroradiology, CHRU Pitié Salpêtrière, Paris, France)
Bruno Law-ye (Sorbonne Univ, UPMC Univ Paris 06, UM 75, ICM, F-75013 Paris, France; Neuroradiology, CHRU Pitié Salpêtrière, Paris, France)
Nadya Pyatigorskaya (Sorbonne Univ, UPMC Univ Paris 06, UM 75, ICM, F-75013 Paris, France; Neuroradiology, CHRU Pitié Salpêtrière, Paris, France)
Ali Bouyahia (Sorbonne Univ, UPMC Univ Paris 06, UM 75, ICM, F-75013 Paris, France; Inserm, U1127, ICM, F-75013 Paris, France; CNRS, UMR 7225, ICM, F-75013 Paris, France; ICM, Paris, France; Inria, Aramis project-team, Centre Paris-Rocquencourt, France; CATI, Paris, France)
Nathalie Thiery (CIC-EC7, CHU de Bordeaux, Pole de Sante Publique, Bordeaux, France)
Carole Dufouil (CIC-EC7, CHU de Bordeaux, Pole de Sante Publique, Bordeaux, France; Univ. Bordeeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique & CIC-EC7, Bordeaux, France)
Christine Delmaire (Neuroradiology, CHRU Roger Salengro, Lille, France)
Didier Dormont (Sorbonne Univ, UPMC Univ Paris 06, UM 75, ICM, F-75013 Paris, France; Inserm, U1127, ICM, F-75013 Paris, France; CNRS, UMR 7225, ICM, F-75013 Paris, France; ICM, Paris, France; Inria, Aramis project-team, Centre Paris-Rocquencourt, France; Neuroradiology, CHRU Pitié Salpêtrière, Paris, France)
Ludovic de Rochefort (Univ. Paris-Saclay, CNRS IR4M UMR8081, Orsay, France)
Marie Chupin (Sorbonne Univ, UPMC Univ Paris 06, UM 75, ICM, F-75013 Paris, France; Inserm, U1127, ICM, F-75013 Paris, France; CNRS, UMR 7225, ICM, F-75013 Paris, France; ICM, Paris, France; Inria, Aramis project-team, Centre Paris-Rocquencourt, France)

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 16 weeks

 

Abstract | Full Text

Introduction/purpose: In vivo detection of cerebral microbleeds (CMBs) from T2* gradient recalled echo (GRE) magnitude image suffers from low specificity, modest inter-rater reproducibility and is biased by its sensitivity to acquisition parameters. New methods were proposed for improving this identification, but they mostly rely on 3D acquisitions, not always feasible in clinical practice. A fast 2D phase processing technique for computing internal field maps (IFM) has been shown to make it possible to characterize CMBs through their magnetic signature in routine clinical setting, based on 2D multi-slice acquisitions. However, its clinical interest for CMBs identification with respect to more common images remained to be assessed. To do so, systematic experiments were undertaken to compare the ratings obtained by trained observers with several image types, T2* magnitude, Susceptibility Weighted Imaging reconstructions (SWI) and IFM built from the same T2*-weighted acquisition. Materials/methods: 15 participants from the MEMENTO multi-center cohort were selected: six subjects with numerous CMBs (20 ± 6 CMBs), five subjects with a few CMBs (2 ± 1 CMBs) and four subjects without CMB. 2D multi-slice T2* GRE sequences were acquired on Philips and Siemens 3T systems. After pilot experiments, T2* magnitude, Susceptibility Weighted Imaging (SWI) minimum intensity projection (mIP) on three slices and IFM were considered for the rating experiments. A graphical user interface (GUI) was designed in order to consistently display images in random order. Six raters of various background and expertise independently selected “definite” or “possible” CMBs. Rating results were compared with respect to a specific consensus reference, on both lesion and subject type points of view. Results: IFM yielded increased sensitivity and decreased false positives rate (FPR) for CMBs identification compared to T2* magnitude and SWI-mIP images. Inter-rater variability was decreased with IFM when identifying subjects with numerous lesions, with only a limited increase in rating time. IFM thus appears as an interesting candidate to improve CMBs identification in clinical setting. Keywords: Microbleeds, Magnetic susceptibility, Phase MRI, SWI