Nature Communications (Oct 2020)

YAP and TAZ protect against white adipocyte cell death during obesity

  • Lei Wang,
  • ShengPeng Wang,
  • Yue Shi,
  • Rui Li,
  • Stefan Günther,
  • Yu Ting Ong,
  • Michael Potente,
  • Zuyi Yuan,
  • Enqi Liu,
  • Stefan Offermanns

DOI
https://doi.org/10.1038/s41467-020-19229-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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The expansion of the white adipose tissue during obesity is accompanied by increased cellular stress, but factors that protect adipocytes from cell death are not well known. Here the authors report that the transcriptional co-activators YAP and TAZ are activated in adipocytes during obesity, which increases adipocyte survival through the proapoptotic factor BIM.