Hepatic decompensation associated with an interferon-free antiviral therapy in patients with HCV-cirrhosis

Abstract

Today, there is no complete clarity about the pathogenetic mechanisms of the hepatic decompensation in patients with HCV-cirrhosis during the course of direct-acting antiviral (DAAs) therapy. The current article describes several clinical observations of decompensation (with the development of liver failure and portal hypertension) in cirrhotic patients during the course of DAAs-therapy of hepatitis C. The authors present contemporary views and their own assumptions about the possible mechanisms of the hepatic decompensation associated with DAAs-therapy in patients with liver cirrhosis.

Keywords

• hepatitis c
• cirrhosis
• antiviral therapy
• direct-acting antiviral agents
• decompensation