Nature Communications (Jan 2020)
ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
- Liyuan Mao,
- Yan-yan Zhan,
- Bin Wu,
- Qiang Yu,
- Liang Xu,
- Xiaoting Hong,
- Linhai Zhong,
- Panying Mi,
- Li Xiao,
- Xinquan Wang,
- Hanwei Cao,
- Wenqing Zhang,
- Binbin Chen,
- Jingzhou Xiang,
- Kunrong Mei,
- Ravi Radhakrishnan,
- Wei Guo,
- Tianhui Hu
Affiliations
- Liyuan Mao
- Cancer Research Center, School of Medicine, Xiamen University
- Yan-yan Zhan
- Cancer Research Center, School of Medicine, Xiamen University
- Bin Wu
- Department of Biology, University of Pennsylvania
- Qiang Yu
- Cancer Research Center, School of Medicine, Xiamen University
- Liang Xu
- Cancer Research Center, School of Medicine, Xiamen University
- Xiaoting Hong
- Cancer Research Center, School of Medicine, Xiamen University
- Linhai Zhong
- Cancer Research Center, School of Medicine, Xiamen University
- Panying Mi
- Cancer Research Center, School of Medicine, Xiamen University
- Li Xiao
- Cancer Research Center, School of Medicine, Xiamen University
- Xinquan Wang
- School of Life Sciences, Tsinghua University
- Hanwei Cao
- Cancer Research Center, School of Medicine, Xiamen University
- Wenqing Zhang
- Cancer Research Center, School of Medicine, Xiamen University
- Binbin Chen
- Cancer Research Center, School of Medicine, Xiamen University
- Jingzhou Xiang
- Cancer Research Center, School of Medicine, Xiamen University
- Kunrong Mei
- School of Pharmaceutical Science and Technology, Tianjin University
- Ravi Radhakrishnan
- Department of Bioengineering, School of Engineering, University of Pennsylvania
- Wei Guo
- Department of Biology, University of Pennsylvania
- Tianhui Hu
- Cancer Research Center, School of Medicine, Xiamen University
- DOI
- https://doi.org/10.1038/s41467-019-13923-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Elevated expression of ULK1 is known to be inversely correlated with breast cancer metastasis. Here, the authors report Exo70 as a substrate of ULK1 that suppresses cancer metastasis, and show that ERK1/2 mediated phosphorylation of Exo70 leads to opposing effects on tumour cell invasion.
