Nature Communications (Dec 2022)
Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation
- Xing Chen,
- Chunyu Yu,
- Xinhua Liu,
- Beibei Liu,
- Xiaodi Wu,
- Jiajing Wu,
- Dong Yan,
- Lulu Han,
- Zifan Tang,
- Xinyi Yuan,
- Jianqiu Wang,
- Yue Wang,
- Shumeng Liu,
- Lin Shan,
- Yongfeng Shang
Affiliations
- Xing Chen
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University
- Chunyu Yu
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University
- Xinhua Liu
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University
- Beibei Liu
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University
- Xiaodi Wu
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University
- Jiajing Wu
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University
- Dong Yan
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University
- Lulu Han
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University
- Zifan Tang
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University
- Xinyi Yuan
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University
- Jianqiu Wang
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University
- Yue Wang
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University
- Shumeng Liu
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University
- Lin Shan
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University
- Yongfeng Shang
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University
- DOI
- https://doi.org/10.1038/s41467-022-35334-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
The carbohydrate binding protein galectin-3 has been linked to diabetes and cancer. Here, authors show that galectin-3 is a sensor of LPS, an important modulator of the mTORC1 signaling, and a critical regulator of glucose metabolism.
