Annals of Clinical and Translational Neurology (Nov 2020)

Role of homocysteine in the development and progression of Parkinson’s disease

  • Xiaoyan Fan,
  • Lixia Zhang,
  • Haijun Li,
  • Guang Chen,
  • Gangqiao Qi,
  • Xueqiang Ma,
  • Yuelei Jin

DOI
https://doi.org/10.1002/acn3.51227
Journal volume & issue
Vol. 7, no. 11
pp. 2332 – 2338

Abstract

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Abstract Homocysteine is an essential intermediate product of biochemical reactions that is present in various tissues of the human body. Homocysteine may be associated with the development and progression of Parkinson’s disease. Plasma homocysteine levels in patients with Parkinson’s disease are elevated compared to those of healthy individuals. High homocysteine drives PD development and progression while aggregating the clinical symptoms of PD patients. The relationship between PD and homocysteine involves multiple pathways, including nerve cell apoptosis, oxidative stress, and DNA damage. This is crucial for explaining how high homocysteine drives the PD procession. Elevated homocysteine level during PD development and progression offers a new strategy for the diagnosis and treatment of this disease.

Keywords